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Space Exploration Initiative
Cultivating wisdom through evolutionary and ecological engineering
Health 0.0
Unnatural Selection tackles tough questions about CRISPR gene editing, designer babies, and more.
How does one scientist deal with the potential ramifications of his own creation?
Sparking discussion about the social, cultural, and ethical implications of emerging technologies through design and storytelling
A new method for sequencing the genome of an intact single cell may help researchers understand how key autism genes are regulated.
Lyme disease is the most common vector-borne infection in North America. People are infected when bitten by ticks; ticks are typically in...
Open Ocean
Engineering at the limits of complexity with molecular-scale parts
The menacing mites have invaded suburban backyards and even parts of Boston. And Lyme disease isn’t the only thing they carry.
Kevin Esvelt writes about the Sculpting Evolution group’s project to immunize mice against Lyme disease through gene editing.
The Māori of Aotearoa (New Zealand) have a long and deep connection to their island and ocean ecosystem. Concepts such as ...
On Should This Exist?, Sculpting Evolution head Kevin Esvelt grapples with the potential benefits and consequences of gene drive.
Center for Extreme Bionics
How will gene drive systems evolve once released into the wild? Can they be reliably overwritten and blocked by immunizing reversal drive...
A conversation between Ed Boyden and Tyler Cowen on optogenetics and expansion microscopy to storytelling and the nature of consciousness.
Who should decide whether, when, and how to alter the environment? These are hard questions, especially when the decisions will impact pe...
In a paper published in PNAS, researchers at MIT and Harvard University describe a self-limiting gene drive system.
Revealing insights into the human condition and repairing brain disorders via novel tools for mapping and fixing brain computations
Scientists hope these genetically modified "gene drive" mosquitoes could help eradicate malaria.
Cummings School and MIT are working with Massachusetts citizens to deploy immune mice as frontline soldiers in the war against the disease.
iBiology features two introductory classes from CRISPR expert Kevin Esvelt, head of the Media Lab's Sculpting Evolution group.
Unlike a normal edit, gene drive systems could lastingly alter or suppress local or global populations of a target species.
We'd like to introduce you to a very special neuroscience project that we are currently conducting in the setting of a traditional fine a...
The widespread synthesis of common organic building blocks in space could have biased life beyond Earth towards chemical similarities to ...
Noah Jakimo, Pranam Chatterjee, Joseph M. Jacobson. Chimeric CRISPR guides enhance Cas9 target specificity, doi: https://doi.org/10.1101/147686
The reproductive organs of the female body have long been a site of contention, where opposing ideologies in religion, politics, and cult...
We are currently developing novel DNA editing technologies to broaden the scope of genome engineering. Our strategy is based on identifyi...
Responsive Science is a way of conducting research that invites openness and community involvement from the earliest stages of each proje...
Residents are invited to weigh in on a plan to release genetically-modified mice on Nantucket to combat tick-borne diseases
Black-legged ticks in forests of the Northeast and Midwest have a variety of options for the three blood meals they consume in their life...
Pursue modular "daisy drive" platforms with the potential to safely, efficiently, and reversibly edit local sub-populations of organisms
Kevin Esvelt has emerged as a leader in the debate about the ethics and politics of releasing genetically engineered animals.
The initiative, working with George Church, professor of genetics at Harvard Medical School, and Kevin Esvelt, head of the Sculpting Evol...
Transdisciplinary artist Ani Liu spoke to us about her project as commentary on the state of reproductive rights today.
Kevin Esvelt leads the Sculpting Evolution Group at MIT. Their work explores “evolutionary and ecological engineering and responsive science
A transgenic chicken commercial for ovulating womenEsgtrogen Farms is a fictional company that raises genetically modified chickens that ...
We collaborated with NIAS (National Institute of Agricultural Science) to genetically engineer silkworms to develop new kinds of silk for...
Imagine you could edit a mouse’s genes to be resistant to Lyme Disease. The mouse would breed and evolution would take its course, leadin...