The rapid advancement of electronic devices and fabrication technologies has further promoted the field of wearables and smart textiles. However, most of the current efforts in textile electronics focus on a single modality and cover a small area. In this work, we introduce a new platform of modular, conformable (i.e., flexible and stretchable) distributed sensor networks that can be embedded into digitally-knit textiles. This platform can be customized for various forms, sizes and functions using standard, accessible and high-throughput textile manufacturing and garment patterning techniques. Here, we have developed a tailored, electronic textile conformable suit (E-TeCS) to perform large-scale, multi-modal physiological (temperature, heart rate, and respiration) sensing in vivo.