Cultivating wisdom through evolutionary and ecological engineering
Heritable immunization of mice against Lyme disease enables ecological disease prevention
Buchthal, J., Chory, E.J., Hill, Z. et al. Heritable immunization of mice against Lyme disease enables ecological disease prevention. Nat Commun (2026). https://doi.org/10.1038/s41467-026-71757-6
Non-invasive ovulation tracking enables genetic engineering in wild rodents
Buchthal, Joanna et al. "Non-invasive ovulation tracking enables genetic engineering in wild rodents." Cell Reports Methods, Volume 6, Issue 2, 101311
LLMs Outperform Experts on Challenging Biology Benchmarks
Justen, L. (2025). Llms outperform experts on challenging biology benchmarks (No. arXiv:2505.06108). arXiv. https://doi.org/10.48550/arXiv.2505.06108
PyLabRobot: An open-source, hardware-agnostic interface for liquid-handling robots and accessories
Rick P. Wierenga, Stefan M. Golas, Wilson Ho, Connor W. Coley, Kevin M. Esvelt. PyLabRobot: An open-source, hardware-agnostic interface for liquid-handling robots and accessories. Device, Volume 1, Issue 4 (2023) https://doi.org/10.1016/j.device.2023.100111.
Systematic molecular evolution enables robust biomolecule discovery
DeBenedictis, E.A., Chory, E.J., Gretton, D.W. et al. Systematic molecular evolution enables robust biomolecule discovery. Nat Methods (2021). https://doi.org/10.1038/s41592-021-01348-4
Enabling high-throughput biology with flexible open-source automation
Mol Syst Biol. 2021 Mar;17(3):e9942. doi: 10.15252/msb.20209942.
A Scalable Solution for Signaling Face Touches to Reduce the Spread of Surface-based Pathogens
Camilo Rojas, Niels Poulsen, Mileva Van Tuyl, Daniel Vargas, Zipporah Cohen, Joe Paradiso, Pattie Maes, Kevin Esvelt, and Fadel Adib. 2021. A Scalable Solution for Signaling Face Touches to Reduce the Spread of Surface-based Pathogens.. Proc. ACM IMWUT
Bidirectional contact tracing is required for reliable COVID-19 control
Bradshaw, W., Alley, E., Huggins, J., Lloyd, A., & Esvelt, K. (2020). Bidirectional contact tracing is required for reliable COVID-19 control. medRxiv. https://doi.org/10.1101/2020.05.06.20093369
Daisy-chain gene drives for the alteration of local populations
Noble, Charleston, John Min, Jason Olejarz, Joanna Buchthal, Alejandro Chavez, Andrea L. Smidler, Erika A. DeBenedictis, George M. Church, Martin A. Nowak, and Kevin M. Esvelt. “Daisy-Chain Gene Drives for the Alteration of Local Populations.” Proceedings of the National Academy of Sciences, April 2, 2019, 201716358. https://doi.org/10.1073/pnas.1716358116.
Current CRISPR gene drive systems are likely to be highly invasive in wild populations
eLife 2018;7:e33423 DOI: 10.7554/eLife.33423
Flexible open-source automation for robotic bioengineering
Emma J Chory, Dana W Gretton, Erika A DeBenedictis, Kevin M Esvelt. "Flexible open-source automation for robotic bioengineering." bioRxiv 2020.04.14.041368; doi: https://doi.org/10.1101/2020.04.14.041368 [This article is a preprint and has not been certified by peer review]