A modular, membrane protein design based biomimetic sensing system named RESENSA (Receptor S-layer Electrical Nano Sensing Array) can transduce biological response to electrical outputs, and enable multiplex sensors for tailored diagnostics.
The RESENSA sensing device has an array of 200 individual sensors with QTY code designed water-soluble CXCR4 receptors that are anchored on an S-layer protein 2D crystal lattice with 100% binding sites upward exposing to external molecules. The S-layer protein 2D crystal lattice not only serves as the anchor, but also serves as a soft carpet to keep CXCR4 receptor proteins stable. The sensor has a density of ~4 trillion per square centimeters.