In collaboration with Prof. Tao Fei’s lab (Shanghai Jiaotong University, China)
In addition to a large number of membrane proteins that comprise most alpha-helix transmembrane segments, there are also many transmembrane proteins with mostly beta-sheets, called beta-barrel membrane proteins. These beta-barrel proteins are often involved in molecular transports. Some are enzymes that are involved in lipid metabolism. We now use the QTY code to design water-soluble beta-barrel transmembrane proteins. Such water-soluble, beta-barrel proteins will facilitate studies of the molecular mechanisms of high selectivity of molecular transport and how these beta-barrel membrane proteins carry out lipid catalysis and metabolism. New insight gained from these studies may be useful for further designs of new molecular devices.