We believe that tough global health problems require an innovation pipeline. We must bring together the people and providers facing health challenges to form what we call an innovation continuum: inventors building new low-cost technologies; developers capable of rapidly iterating on these inventions for use in the real world; clinicians and end users to validate our creations; and entrepreneurs, philanthropists, and development agencies to scale our solutions. We are asking big questions such as: What billion-dollar ideas could impact a billion lives in health, education, transportation through digital interfaces, digital opportunities, and applications for physical systems? Using machine learning, computer vision, big data, sensors, mobile technology, diagnostics, and crowdsourcing, we are conducting research at the Media Lab, and also collaborating with innovators in three centers in India and in other centers worldwide. Innovations like this launched the effort to create the Emerging Worlds initiative.