Lyme disease is the most common vector-borne infection in North America. People are infected when bitten by ticks — and ticks usually become infected after feeding on white-footed mice, a key reservoir of the disease. Our project explores the possibility of permanently immunizing mouse populations to block transmission, by creating mice that produce protective antibodies from birth and pass immunity to their pups. From the very beginning, representatives from offshore island communities have helped guide the project. These communities will help choose which antibodies to use, identify uninhabited islands for field trials, select independent monitors, and ultimately decide whether to volunteer their own islands for the next stage. If successful, this approach could one day be expanded to the mainland. Whether or not communities choose to proceed, we hope this effort will serve as a model for how science can responsibly respond to public health challenges. Learn more here: https://www.miceagainstticks.org/