This research aims to address the timely and timeless challenge of human-computer interaction by focusing on designing and studying human-AI systems for human flourishing. The timeliness of this research is evident as we become increasingly integrated with intelligent machines, evolving into what Manfred E. Clynes and Nathan S. Kline described as cyborgs . Understanding how technology influences our psychology is crucial for developing systems that promote human values and foster human thriving. Simultaneously, the quest for human flourishing is a timeless endeavor, pursued by scholars across disciplines, from ancient philosophers to modern behavioral scientists. While this work does not claim to fully resolve these profound issues, we aim to provide guidance for designing future systems that support and enhance human flourishing, while simultaneously envisioning a rich, humanistic future not driven solely by technological progress. By synthesizing insights from diverse fields and applying them to the emerging realm of human-AI interaction, we present research studies, experimental prototypes, and a research framework for technological development that prioritizes human values and flourishing, balancing advancement with a deep consideration for the human experience.