New approach reveals genomes' sequence and structure directly within cells

By Jennifer Michalowski

By bringing DNA sequencing out of the sequencer and directly to cells, scientists from the McGovern Institute for Brain Research, the Harvard University Department of Stem Cell and Regenerative Biology (HSCRB), and the Broad Institute of MIT and Harvard have revealed an entirely new view of the genome. With a new method for in situ genome sequencing reported in Science, researchers can, for the first time, see exactly how DNA sequences are organized and packed inside cells.

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